Since the first calisthenics program was introduced in the 1950s, with older children racing rubber tires across the playground at recess and the younger ones learning to jump through them, St. Andrew's athletic programming has come a long way. 

In the mid-1970s, St. Andrew’s joined the Mississippi High School Activities Association and fielded teams in football, baseball, basketball, track, golf, and tennis and started the first high school soccer program in Mississippi. 

The winning tradition began in 1977 when the baseball team brought home the Saints’ first state championship trophy. The Saints have won at least one state championship (and typically more) every year since for a total of 134. 

In the 1990s, St. Andrew's won its first All-Sports award in 2A. Since then, St. Andrew's has won the award 28 times in either 2A or 3A. In the same decade, the school fielded the state's first lacrosse team. 

Most recently, St. Andrew's created the first wrestling team in a private school in Mississippi and also launched an equestrian club and a clay pigeon shooting club.